中文名 硫黄素T
英文名 2-[4-(dimethylamino)phenyl]-3,6-dimethylbenzothiazolium chloride
别名 盐基嫩黄
碱性黄1
硫磺素T
硫黄素T
硫黄素 T
碱性黄 1
硫代黄素T
硫代磺素T
硫代黄色素 T
2-[4-(二甲基氨基)苯基]-3,6-二甲基苯并噻唑鎓氯化物
英文别名 avin T
ThiofL
C.I. 49005
Thioflavin T
Thioflavine T
C.I. Basic Yellow 1
LABOTEST-BB LT00451909
Thioflavine T (C.I.No.49005) for synthesis
2-[4-(dimethylamino)phenyl]-3,6-dimethyl-benzothiazoliuchloride
2-[4-(dimethylamino)phenyl]-3,6-dimethylbenzothiazolium chloride
Benzothiazolium,2-[4-(dimethylamino)phenyl]-3,6-dimethyl-,chloride
2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium chloride
CAS 2390-54-7
EINECS 219-228-9
化学式 C17H19ClN2S
分子量 318.86
InChI InChI=1/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1
密度 1.301g/cm3 at 20℃
熔点 211-212 °C (decomp)
蒸汽压 0Pa at 25℃
溶解度 methanol: soluble1mg/mL
存储条件 Store below +30°C.
外观 Powder
颜色 Yellow to ochre-yellow
BRN 3922452
MDL号 MFCD00011944
体外研究 Thioflavin T (ThT) is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, Thioflavin T is found to exist as micelles at concentrations commonly used to monitor fibrils by fluorescence assay (~10-20 μM). Specific conductivity changes are measured at varying concentration of Thioflavin T and the critical micellar concentration is calculated to be 4.0±0.5 μM. Changes in the fluorescence excitation and emission of Thioflavin T are also dependent on the micelle formation. The Thioflavin T micelles of 3 nm diameter are directly visualized using atomic force microscopy, and bound Thioflavin T micelles are observed along the fibril length for representative fibrils. Increasing concentration of Thioflavin T above the critical micellar concentration shows increased numbers of micelles bound along the length of the amyloid fibrils. Thioflavin T micelles are disrupted at low pH as observed by atomic force microscopy and fluorescence enhancement upon binding of Thioflavin T to amyloid fibrils also reduced by several-fold upon decreasing the pH to below 3.The micelles of Thioflavin T bind amyloid fibrils leading to enhancement of fluorescence emission.
安全术语 24/25 - 避免与皮肤和眼睛接触。
危险品运输编号 2811
WGK Germany 3
TSCA Yes
Hazard Class 6.1(b)
Packing Group III
上游原料 2-(4-氨基苯基)-6-甲基苯并噻唑
CAS NO：2390-54-7
EC NO：219-228-9
分子式：C17H19ClN2S
分子量：318.8642
别 名：;硫黄素 T;碱性黄 1;2-[4-(二甲基氨基)苯基]-3,6-二甲基苯并噻唑鎓氯化物;黄染料;
结构式：
